Synthesis and evaluation of the biological activity of N `-2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents
Data(s) |
2015
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Resumo |
New N'-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide derivatives were synthesized and evaluated for their cytotoxic properties against murine leukemia, L1210, human leukemia, REH and K562, human T-cell leukemia, CEM and human cervix carcinoma, HeLa cells. Among the tested compounds, the 3,4,5-trimethoxy-N'-5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]ben zohydrazide derivative (5t) emerged as the most potent inhibitor against all the tumor cell lines evaluated. To investigate the mechanism of action, 5t was further studied by cell cycle analysis, mitochondrial membrane potential analysis, DNA fragmentation and Annexin V-FITC flow cytometric analysis, which suggested that 5t was able to induce apoptosis at submicromolar range. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/51791/1/Rsc_Adv_5-56_45492_2015.pdf Katiyar, Arpit and Hegde, Mahesh and Kumar, Sujeet and Gopalakrishnan, Vidya and Bhatelia, Khyati D and Ananthaswamy, Kavya and Ramareddy, Sureshbabu A and De Clercq, Erik and Choudhary, Bibha and Schols, Dominique and Raghavan, Sathees C and Karki, Subhas S (2015) Synthesis and evaluation of the biological activity of N `-2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents. In: RSC ADVANCES, 5 (56). pp. 45492-45501. |
Publicador |
ROYAL SOC CHEMISTRY |
Relação |
http://dx.doi.org/ 10.1039/c5ra01528f http://eprints.iisc.ernet.in/51791/ |
Palavras-Chave | #Biochemistry |
Tipo |
Journal Article PeerReviewed |