Pluronic copolymer encapsulated SCR7 as a potential anticancer agent
Data(s) |
2015
|
---|---|
Resumo |
Nonhomologous end joining (NHEJ) of DNA double strand breaks (DSBs) inside cells can be selectively inhibited by 5,6-bis-(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) which possesses anticancer properties. The hydrophobicity of SCR7 decreases its bioavailability which is a major setback in the utilization of this compound as a therapeutic agent. In order to circumvent the drawback of SCR7, we prepared a polymer encapsulated form of SCR7. The physical interaction of SCR7 and Pluronic (R) copolymer is evident from different analytical techniques. The in vitro cytotoxicity of the drug formulations is established using the MTT assay. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/51579/1/far_dis-177_155_2015.pdf John, Franklin and George, Jinu and Srivastava, Mrinal and Hassan, PA and Aswal, VK and Karkie, Subhas S and Raghavan, Sathees C (2015) Pluronic copolymer encapsulated SCR7 as a potential anticancer agent. In: FARADAY DISCUSSIONS, 177 . pp. 155-161. |
Publicador |
ROYAL SOC CHEMISTRY |
Relação |
http://dx.doi.org/10.1039/c4fd00176a http://eprints.iisc.ernet.in/51579/ |
Palavras-Chave | #Biochemistry |
Tipo |
Journal Article PeerReviewed |