A quinazoline derivative as quick-response red-shifted reporter for nanomolar Al3+ and applicable to living cell staining
Data(s) |
2014
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Resumo |
A newly synthesized and structurally characterized quinazoline derivative (L) has been shown to act as a quick-response chemosensor for Al3+ with a high selectivity over other metal ions in water-DMSO. In the presence of Al3+, L shows a red-shifted ratiometric enhancement in fluorescence as a result of internal charge transfer and chelation-enhanced fluorescence through the inhibition of a photo-induced electron transfer mechanism. This probe detects Al3+ at concentrations as low as 1.48 nM in 100 mM HEPES buffer (DMSO-water, 1 : 9 v/v) at biological pH with a very short response time (15-20 s). L was applied to biological imaging to validate its utility as a fluorescent probe for monitoring Al3+ ions in living cells, illustrating its value in practical environmental and biological systems. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/50652/1/rsc_adv_4-109_64014_2014.pdf Mukherjee, Manjira and Sen, Buddhadeb and Pal, Siddhartha and Banerjee, Samya and Lohar, Somenath and Chattopadhyay, Pabitra (2014) A quinazoline derivative as quick-response red-shifted reporter for nanomolar Al3+ and applicable to living cell staining. In: RSC ADVANCES, 4 (109). pp. 64014-64020. |
Relação |
http://dx.doi.org/ 10.1039/c4ra10836a http://eprints.iisc.ernet.in/50652/ |
Palavras-Chave | #Inorganic & Physical Chemistry |
Tipo |
Journal Article PeerReviewed |