Seleno-Nucleobases and Their Water-Soluble Ruthenium-Arene Half-Sandwich Complexes: Chemistry and Biological Activity
Data(s) |
2014
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Resumo |
Half-sandwich organometallic ruthenium complexes of seleno-nucleobases, 3 and 4, were synthesized and characterized. The structures of both complexes were determined by X-ray crystallography and are the first crystal structures of ruthenium complexes with seleno-nucleobases. Interestingly, 3 self-assembles aided by adventitious water in DMF to give a tetranuclear square 3a center dot 6H(2)O. Complex 4 is active against Jurkat and Molt-4 cell lines but inactive against the K562 cell line, whereas 3 is completely inactive against all three cell lines. The free ligand 6-selenopurine (1) and 6-selenoguanine (2) are highly active against these cell lines. Compound 2, like its thio analogue, is unstable under UVA light, whereas 4 is stable under similar conditions, which suggests that the ruthenium complex could reduce problems associated with the instability of the free ligand, 2, under irradiation. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/50581/1/eur_jou_ino_che_33-5733_2014.pdf Mitra, Raja and Pramanik, Anup K and Samuelson, Ashoka G (2014) Seleno-Nucleobases and Their Water-Soluble Ruthenium-Arene Half-Sandwich Complexes: Chemistry and Biological Activity. In: EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (33). pp. 5733-5740. |
Publicador |
WILEY-V C H VERLAG GMBH |
Relação |
http://dx.doi.org/ 10.1002/ejic.201402412 http://eprints.iisc.ernet.in/50581/ |
Palavras-Chave | #Instrumentation and Applied Physics (Formally ISU) |
Tipo |
Journal Article PeerReviewed |