Regioselective Synthesis of 4-Substituted Indoles via C-H Activation: A Ruthenium Catalyzed Novel Directing Group Strategy


Autoria(s): Lanke, Veeranjaneyulu; Prabhu, Kandikere Ramaiah
Data(s)

2013

Resumo

A highly regioselective functionalization of indole at the C-4 position by employing an aldehyde functional group as a directing group, and Ru as a catalyst, under mild reaction conditions (open flask) has been uncovered. This strategy to synthesize 4-substituted indoles is important, as this class of privileged molecules serves as a precursor for ergot alkaloids and related heterocyclic compounds.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/48300/1/Org_Let_15-24_6262_2013.pdf

Lanke, Veeranjaneyulu and Prabhu, Kandikere Ramaiah (2013) Regioselective Synthesis of 4-Substituted Indoles via C-H Activation: A Ruthenium Catalyzed Novel Directing Group Strategy. In: ORGANIC LETTERS, 15 (24). pp. 6262-6265.

Publicador

AMER CHEMICAL SOC

Relação

http://dx.doi.org/10.1021/ol4031149

http://eprints.iisc.ernet.in/48300/

Palavras-Chave #Organic Chemistry
Tipo

Journal Article

PeerReviewed