Design and synthesis of positional isomers of 5 and 6-bromo-1-(phenyl)sulfonyl]-2-(4-nitrophenoxy)methyl]-1H-benzimida zoles as possible antimicrobial and antitubercular agents
Data(s) |
15/09/2013
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Resumo |
In this Letter, we report the structure activity relationship (SAR) studies on series of positional isomers of 5(6)-bromo-1-(phenyl)sulfonyl]-2-(4-nitrophenoxy)methyl]-1H-benzim idazoles derivatives 7(a-j) and 8(a j) synthesized in good yields and characterized by H-1 NMR, C-13 NMR and mass spectral analyses. The crystal structure of 7a was evidenced by X-ray diffraction study. The newly synthesized compounds were evaluated for their in vitro antibacterial activity against Staphylococcus aureus, (Gram-positive), Escherichia coil and Klebsiella pneumoniae (Gram-negative), antifungal activity against Candida albicans, Aspergillus flavus and Rhizopus sp. and antitubercular activity against Mycobacterium tuberculosis H37Rv, Mycobacterium smegmatis, Mycobacterium fortuitum and MDR-TB strains. The synthesized compounds displayed interesting antimicrobial activity. The compounds 7b, 7e and 7h displayed significant activity against Mycobacterium tuberculosis H37Rv strain. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/47474/1/Bioor_Medi_Chem_Lett_23-18_%205228_2013.pdf Ranjith, Karuvalam P and Rajeesh, P and Haridas, Karickal R and Susanta, Nayak K and Row, Guru Tayur N and Rishikesan, R and Kumari, Suchetha N (2013) Design and synthesis of positional isomers of 5 and 6-bromo-1-(phenyl)sulfonyl]-2-(4-nitrophenoxy)methyl]-1H-benzimida zoles as possible antimicrobial and antitubercular agents. In: Bioorganic & Medicinal Chemistry Letters, 23 (18). pp. 5228-5234. |
Publicador |
Elsevier Science |
Relação |
http://dx.doi.org/10.1016/j.bmcl.2013.06.072 http://eprints.iisc.ernet.in/47474/ |
Palavras-Chave | #Solid State & Structural Chemistry Unit |
Tipo |
Journal Article PeerReviewed |