Surface modification and paclitaxel drug delivery of folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles


Autoria(s): Venkatasubbu, Devanand G; Ramasamy, S; Avadhani, GS; Ramakrishnan, V; Kumar, J
Data(s)

2013

Resumo

Nanoparticles are used for a number of biomedical applications. In this work we report the synthesis of folic acid (FA) modified polyethylene glycol (PEG) functionalized hydroxyapatite (HAp) nanoparticles. The anticancer drug, paclitaxel, is attached to the folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles and the in vitro drug release is analyzed. The surface modification and functionalization is confirmed by Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA) and UV spectroscopy. The importance of the paper is the investigation of the release behavior of paclitaxel conjugated folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles. The results show an initial rapid release and then a sustained release. (C) 2012 Elsevier B.V. All rights reserved.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/46469/1/pow_tec_235_437_2013.pdf

Venkatasubbu, Devanand G and Ramasamy, S and Avadhani, GS and Ramakrishnan, V and Kumar, J (2013) Surface modification and paclitaxel drug delivery of folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles. In: POWDER TECHNOLOGY, 235 . pp. 437-442.

Publicador

ELSEVIER SCIENCE SA

Relação

http://dx.doi.org/10.1016/j.powtec.2012.11.003

http://eprints.iisc.ernet.in/46469/

Palavras-Chave #Materials Engineering (formerly Metallurgy)
Tipo

Journal Article

PeerReviewed