Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization
| Data(s) |
2013
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|---|---|
| Resumo |
hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic beta-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (Delta F) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects beta-cells from hIAPP induced toxicity. |
| Formato |
application/pdf |
| Identificador |
http://eprints.iisc.ernet.in/46329/1/che_com_49_26_2688_2013.pdf Mishra, Aseem and Misra, Anurag and Vaishnavi, SriT and Thota, Chaitanya and Gupta, Madhvi and Ramakumar, Suryanarayanarao and Chauhan, Virander Singh (2013) Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization. In: CHEMICAL COMMUNICATIONS, 49 (26). pp. 2688-2690. |
| Publicador |
ROYAL SOC CHEMISTRY |
| Relação |
http://dx.doi.org/10.1039/c3cc38982k http://eprints.iisc.ernet.in/46329/ |
| Palavras-Chave | #Physics |
| Tipo |
Journal Article PeerReviewed |
