Non-neutral evolution in non-LEE-encoded type III effectors of attaching and effacing Escherichia coli


Autoria(s): Eswarappa, Sandeepa M; Janice, Jessin; Balasundaram, Sudhagar V; Chakravortty, Dipshikha
Data(s)

2013

Resumo

Attaching and effacing Escherichia coli (AEEC) employ type III secretion system (T3SS) to secrete effector proteins into host cells and regulate their function. Here we have investigated T3SS genes of AEEC for non-neutral evolution. Our analysis revealed non-neutral evolution in three genes (nleE1, nleB2 and nleD) which encode effector proteins. These genes are located outside the locus of enterocyte effacement (LEE). In general, non-LEE effector genes show greater deviation from neutral evolution than LEE effector genes. These results suggest that effector genes located outside LEE are under greater selection pressure than those present in LEE. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/46076/1/mic_inf_15-2_147_2013.pdf

Eswarappa, Sandeepa M and Janice, Jessin and Balasundaram, Sudhagar V and Chakravortty, Dipshikha (2013) Non-neutral evolution in non-LEE-encoded type III effectors of attaching and effacing Escherichia coli. In: MICROBES AND INFECTION, 15 (2). pp. 147-151.

Publicador

ELSEVIER SCIENCE BV

Relação

http://dx.doi.org/10.1016/j.micinf.2012.10.015

http://eprints.iisc.ernet.in/46076/

Palavras-Chave #Microbiology & Cell Biology
Tipo

Journal Article

PeerReviewed