Catalytic Asymmetric Synthesis of alpha,beta-Disubstituted alpha,gamma-Diaminophosphonic Acid Precursors by Michael Addition of alpha-Substituted Nitrophosphonates to Nitroolefins
Data(s) |
01/07/2012
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Resumo |
Michael additions of alpha-substituted nitrophosphonates to various nitroolefins are shown to proceed with high diastereo- and enantioselectivity when catalyzed by a quinine-derived thiourea-tertiary amine bifunctional catalyst and generate alpha,gamma-diaminophosphonic acid precursors with contiguous quaternary and tertiary stereocenters. |
Formato |
application/pdf application/pdf application/pdf text/plain |
Identificador |
http://eprints.iisc.ernet.in/44921/1/org_let_14-13_3296-3299_2012.pdf http://eprints.iisc.ernet.in/44921/2/ol3012666_si_001.pdf http://eprints.iisc.ernet.in/44921/3/ol3012666_si_002.pdf http://eprints.iisc.ernet.in/44921/4/ol3012666_si_003.cif Tripathi, Chandra Bhushan and Kayal, Satavisha and Mukherjee, Santanu (2012) Catalytic Asymmetric Synthesis of alpha,beta-Disubstituted alpha,gamma-Diaminophosphonic Acid Precursors by Michael Addition of alpha-Substituted Nitrophosphonates to Nitroolefins. In: ORGANIC LETTERS, 14 (13). pp. 3296-3299. |
Publicador |
AMER CHEMICAL SOC |
Relação |
http://dx.doi.org/10.1021/ol3012666 http://eprints.iisc.ernet.in/44921/ |
Palavras-Chave | #Organic Chemistry |
Tipo |
Journal Article PeerReviewed |