Catalytic enantioselective construction of quaternary stereocenters by direct vinylogous Michael addition of deconjugated butenolides to nitroolefins
Data(s) |
01/03/2012
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Resumo |
A direct vinylogous Michael reaction of gamma-substituted deconjugated butenolides with nitroolefins has been developed with the help of a newly identified quinine-derived bifunctional catalyst, allowing the synthesis of densely functionalized products with contiguous quaternary and tertiary stereocenters in excellent yield with perfect diastereoselectivity (>20 : 1 dr) and high enantioselectivity (up to 99 : 1 er). |
Formato |
application/pdf application/pdf |
Identificador |
http://eprints.iisc.ernet.in/44556/1/chem_comm_48_5193-5195.pdf http://eprints.iisc.ernet.in/44556/2/chem_comm_48_5193-5195-supp_2012.pdf Manna, Madhu Sudan and Kumar, Vikas and Mukherjee, Santanu (2012) Catalytic enantioselective construction of quaternary stereocenters by direct vinylogous Michael addition of deconjugated butenolides to nitroolefins. In: CHEMICAL COMMUNICATIONS, 48 (42). pp. 5193-5195. |
Publicador |
Royal Society of Chemistry |
Relação |
http://dx.doi.org/10.1039/C2CC31700A http://eprints.iisc.ernet.in/44556/ |
Palavras-Chave | #Organic Chemistry |
Tipo |
Journal Article PeerReviewed |