Layer-by-Layer Assembled Thin Film of Albumin Nanoparticles for Delivery of Doxorubicin


Autoria(s): Mohanta, Vaishalchi; Madras, Giridhar; Patil, Satish
Data(s)

08/03/2012

Resumo

Protein nanoparticles (NPs) have found significant applications in drug delivery due to their inherent biocompatibility, which is attributed to their natural origin. In this study, bovine serum abumin (BSA) nanoparticles were introduced in multilayer thin film via layer-by-layer self-assembly for localized delivery of the anticancer drug Doxorubicin (Dox). BSA nanoparticles (similar to 100 nm) show a high negative zeta potential in aqueous medium (-55 mV) and form a stable dispersion in water without agglomeration for a long period. Hence, BSA NPs can be assembled on a substrate via layer-by-layer approach using a positively charged polyelectrolyte (chitosan in acidic medium). The protein nature of these BSA nanoparticles ensures the biocompatibility of the film, whereas the availability of functional groups on this protein allows one to tune the property of the self-assembly to have a pH-dependent drug release profile. The growth of multilayer thin film was monitored by UV-visible spectroscopy, and the films were further characterized by atomic force microscopy (AFM) and field emission scanning electron microscopy (FESEM). The drug release kinetics of these BSA nanoparticles and their self-assembled thin film has been compared at a physiological pH of 7.4 and an acidic pH of 6.4.

Formato

application/pdf

application/pdf

Identificador

http://eprints.iisc.ernet.in/44253/1/Layer-by.pdf

http://eprints.iisc.ernet.in/44253/2/Supporting_info.pdf

Mohanta, Vaishalchi and Madras, Giridhar and Patil, Satish (2012) Layer-by-Layer Assembled Thin Film of Albumin Nanoparticles for Delivery of Doxorubicin. In: Journal of Physical Chemistry C, 116 (9). pp. 5333-5341.

Publicador

American Chemical Society

Relação

http://pubs.acs.org/doi/abs/10.1021/jp209479n

http://eprints.iisc.ernet.in/44253/

Palavras-Chave #Solid State & Structural Chemistry Unit #Chemical Engineering
Tipo

Journal Article

PeerReviewed