Efficient synthesis of carbonyl compounds: oxidation of azides and alcohols catalyzed by vanadium pentoxide in water using tert-butylhydroperoxide
Data(s) |
04/11/2011
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Resumo |
Catalytic amount of vanadium reagent with tert-butylhydroperoxide as the oxidant was found to be an excellent oxidizing agent in aqueous medium. Vanadium pentoxide with aq tert-butylhydroperoxide readily oxidizes primary benzylic azides to the corresponding acids and secondary benzylic azides to the corresponding ketones in excellent yields. Further, vanadium pentoxide and aq tert-butylhydroperoxide combination turned out to be an effective catalyst for the oxidation of alcohols. Using vanadium pentoxide and aq tert-butylhydroperoxide primary alcohols were oxidized to the corresponding acids, whereas secondary alcohols underwent a smooth transformation to furnish corresponding ketones in excellent yields. All the oxidations are performed in water. (C) 2011 Elsevier Ltd. All rights reserved. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/42055/1/Efficient.pdf Alagiri, Kaliyamoorthy and Prabhu, Kandikere Ramaiah (2011) Efficient synthesis of carbonyl compounds: oxidation of azides and alcohols catalyzed by vanadium pentoxide in water using tert-butylhydroperoxide. In: Tetrahedron, 67 (44). pp. 8544-8551. |
Publicador |
Elsevier Science |
Relação |
http://dx.doi.org/10.1016/j.tet.2011.08.080 http://eprints.iisc.ernet.in/42055/ |
Palavras-Chave | #Organic Chemistry |
Tipo |
Journal Article PeerReviewed |