devovo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite


Autoria(s): Surolia, Namita; Padmanaban, Govindarajan
Data(s)

16/09/1992

Resumo

The human malarial parasite, Image , has been found to synthesize heme Image , despite the accumulation of large quantities of polymeric heme derived from the hemoglobin of the red cell host. The parasite δ-aminolevulinate dehydrase level is significantly lower than that of the host and its inhibition by succinylacetone leads to inhibition of parasite protein synthesis and viability.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/35162/1/-D-_E_NOVO_BIOSYNTHESIS_OF_HEM.pdf

Surolia, Namita and Padmanaban, Govindarajan (1992) devovo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite. In: Biochemical and Biophysical Research Communications, 187 (2). pp. 744-750.

Publicador

Elsevier science

Relação

http://dx.doi.org/10.1016/0006-291X(92)91258-R

http://eprints.iisc.ernet.in/35162/

Palavras-Chave #Biochemistry #Others
Tipo

Journal Article

PeerReviewed