Ability of human chorionic gonadotropin beta-subunit to inhibit the steroidogenic response to lutropin.


Autoria(s): Dighe, RR; Muralidhar, K; Moudgal, NR
Data(s)

1979

Resumo

Ability of the beta-subunit of human chorionic gonadotropin to inhibit the response to lutropin (luteinizing hormone, LH) was tested in the immature rat ovarian system and pregnant-mare-serum-gonadotropin-primed rat ovarian system with progesterone production being used as the response. Human chorionic gonadotropin beta-subunit was found to inhibit human and ovine lutropin-stimulated progesterone production. At a constant dose of lutropin, inhibition was dependent on the concentration of beta-subunit. When concentration of the beta-subunit was kept constant at 5.0 microgram/ml and the concentration of lutropin was varied, the inhibition was maximum at the saturating concentration of the native hormone. The alpha-subunit of the human chorionic gonadotropin did not inhibit the response to lutropin. The lutropin/beta-subunit ratio required to produce an inhibition of response was much lower than that required to bring about an observable inhibition of binding.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/34516/1/Ability.pdf

Dighe, RR and Muralidhar, K and Moudgal, NR (1979) Ability of human chorionic gonadotropin beta-subunit to inhibit the steroidogenic response to lutropin. In: Biochemical Journal, 180 (3). pp. 573-578.

Publicador

Portland Press

Relação

http://journalseek.net/cgi-bin/journalseek/journalsearch.cgi?query=0264-6021+&field=title&editorID=&send=Search+Title%2FISSN+Only

http://eprints.iisc.ernet.in/34516/

Palavras-Chave #Biochemistry
Tipo

Journal Article

PeerReviewed