Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds.


Autoria(s): Bhat, Shama C; Ramasarma, T
Data(s)

1979

Resumo

1. Mevalonate pyrophosphate decarboxylase of rat liver is inhibited by various phenyl and phenolic acids. 2. Some of the phenyl and phenolic acids also inhibited mevalonate phosphate kinase. 3. Compounds with the phenyl-vinyl structure were more effective. 4. Kinetic studies showed that some of the phenolic acids compete with the substrates, mevalonate 5-phosphate and mevalonate 5-pyrophosphate, whereas others inhibit umcompetitively. 5. Dihydroxyphenyl and trihydroxyphenyl compounds and p-chlorophenoxyisobutyrate, a hypocholesterolaemic drug, had no effect on these enzymes. 6. Of the three mevalonate-metabolizing enzymes, mevalonate pyrophosphate decarboxylase has the lowest specific activity and is probably the rate-determining step in this part of the pathway.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/34374/1/inhibition.pdf

Bhat, Shama C and Ramasarma, T (1979) Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds. In: Biochemical Journal, 181 (1). pp. 143-151.

Publicador

Portland Press

Relação

http://www.biochemj.org/bj/default.htm

http://eprints.iisc.ernet.in/34374/

Palavras-Chave #Biochemistry
Tipo

Journal Article

PeerReviewed