Evidence for the formation of a known toxin, P-cresol, from menthofuran
Data(s) |
31/05/1991
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Resumo |
Menthofuran (II, 4,5,6,7-tetrahydro-3,6-dimethyl benzofuran), the proximate toxin of R-(+)-pulegone (I), was administered orally to rats (200 mg/kg of body weight/day) for three days and the urinary metabolites were investigated. Among the several metabolites formed, two of them viz. 4-Hydroxy-4-methyl-2-cyclohexenone (VII) and p-cresol (VIII) were indentified. In support of the formation of these metabolites, it has been demonstrated that phenobarbital induced rat liver microsomes readily convert 4-methyl-2-cyclohexenone (V) to 4-hydroxy-4-methyl-2-cyclohexenone (VII) and p-cresol (VIII) in the presence of NADPH and O2. Possible mechanism for the formation of these two metabolites (VII, VIII) from menthofuran (II) has been proposed. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/33772/1/EVIDENCE_FOR_THE_FORMATION_OF_A.pdf Madyastha, KM and Raj, Paul C (1991) Evidence for the formation of a known toxin, P-cresol, from menthofuran. In: Biochemical and Biophysical Research Communications, 177 (1). 440-446 . |
Publicador |
Elsevier science |
Relação |
http://dx.doi.org/10.1016/0006-291X(91)92003-3 http://eprints.iisc.ernet.in/33772/ |
Palavras-Chave | #Organic Chemistry |
Tipo |
Journal Article PeerReviewed |