Selective para metalation of unprotected 3-methoxy and 3,5-dimethoxy benzoic acids with n-butyl lithium-potassium tert-butoxide (LIC-KOR): synthesis of 3,5-dimethoxy-4-methyl benzoic acid
| Data(s) |
22/04/2000
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| Resumo |
The potassium salt of 3-methoxy and 3,5-dimethoxy benzoic acids undergoes deprotonation at the position para to the carboxylate group selectively when treated with LIC-KOR in THF at -78 degrees C and it has been extended to the synthesis of 3,5-dimethoxy-4-methyl benzoic acid. (C) 2000 Elsevier Science Ltd. All rights reserved. |
| Formato |
application/pdf |
| Identificador |
http://eprints.iisc.ernet.in/31275/1/para.pdf Sinha, Surajit and Mandal, Bhubaneswar and Chandrasekaran, Srinivasan (2000) Selective para metalation of unprotected 3-methoxy and 3,5-dimethoxy benzoic acids with n-butyl lithium-potassium tert-butoxide (LIC-KOR): synthesis of 3,5-dimethoxy-4-methyl benzoic acid. In: Tetrahedron Letters, 41 (17). pp. 3157-3160. |
| Publicador |
Elsevier science |
| Relação |
http://dx.doi.org/10.1016/S0040-4039(00)00320-8 http://eprints.iisc.ernet.in/31275/ |
| Palavras-Chave | #Organic Chemistry |
| Tipo |
Journal Article PeerReviewed |
