A Concise Synthesis of Substituted Thiourea Derivatives in Aqueous Medium
Data(s) |
02/04/2010
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Resumo |
An efficient method for the synthesis of symmetrical and unsymmetrical substituted thiourea derivatives by means of simple condensation between available building blocks such Lis airlines and carbon disulfide in aqueous medium is presented. This protocol works smoothly with aliphatic primary amines to afford various di- and trisubstituted thiourea derivatives. The present method is also useful ill synthesizing various substituted 2-mercapto imidazole heterocycles. This method proceeds through a xanthate (amino dithiol deivative) intermediate, unlike isothiocyanate as in all earlier known method. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/26999/1/joc.pdf Maddani, Mahagundappa R and Prabhu, Kandikere R (2010) A Concise Synthesis of Substituted Thiourea Derivatives in Aqueous Medium. In: Journal of Organic Chemistry, 75 (7). pp. 2327-2332. |
Publicador |
American Chemical Society |
Relação |
http://pubs.acs.org/doi/abs/10.1021/jo1001593 http://eprints.iisc.ernet.in/26999/ |
Palavras-Chave | #Organic Chemistry |
Tipo |
Journal Article PeerReviewed |