Impact of chemotherapy on cancer-related fatigue and cytokines in 1312 patients: A systematic review of quantitative studies


Autoria(s): Eyob, Tewodros; Ng, Terence; Chan, Raymond; Chan, Alexandre
Data(s)

2016

Resumo

Purpose of review: Cancer-related fatigue (CRF) is the most common psychosomatic distress experienced by cancer patients before, during and after chemotherapy. Its impact on functional status and Health Related Quality of Life is a great concern among patients, healthcare professionals and researchers. The primary objective of this systematic review is to determine whether the different chemotherapies affect the association of CRF with individual pro- and anti-inflammatory cytokines. The PRISMA statement guideline has been followed to systematically search and screen article from PubMed and Embase. Recent findings: This review has examined 14 studies which included a total of 1312 patients. These studies assayed 20 different kinds of cytokines. The cytokines interleukin-6, interleukin-1RA, TGF-[beta] and sTNF-R2 were associated with CRF in patients receiving anthracycline-based chemotherapy. However, only interleukin-13 was identified in the taxane-based chemotherapy. Similarly, different sets of cytokines were linked with CRF in patients with chemotherapy regimens containing platinum, cyclophosphamides, topotecan or bleomycin. Summary: This review has identified that cytokines are differentially linked with CRF according to the various types of chemotherapy regimens.

Identificador

http://eprints.qut.edu.au/95080/

Publicador

Lippincott Williams & Wilkins, Ltd.

Relação

DOI:10.1097/SPC.0000000000000205

Eyob, Tewodros, Ng, Terence, Chan, Raymond, & Chan, Alexandre (2016) Impact of chemotherapy on cancer-related fatigue and cytokines in 1312 patients: A systematic review of quantitative studies. Current Opinion in Supportive and Palliative Care. (In Press)

Direitos

Copyright 2016 Wolters Kluwer Health, Inc.

Fonte

Faculty of Health; Institute of Health and Biomedical Innovation; School of Nursing

Palavras-Chave #111000 NURSING #111003 Clinical Nursing - Secondary (Acute Care) #111205 Chemotherapy #111299 Oncology and Carcinogenesis not elsewhere classified #cancer-related fatigue #chemotherapy #cytokines #cancer
Tipo

Journal Article