A multiple nucleotide length polymorphism (MNLP) mediates androgen regulation of IRX4 in prostate cancer
| Data(s) |
2015
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|---|---|
| Resumo |
Androgens and the androgen receptor (AR) play a crucial role in the initiation and progression of prostate cancer (PCa), regulating the expression of many PCa risk-associated genes. Iroquois Homeobox 4 (IRX4) has been recently identified with PCa risk and overexpressed in PCa. We observed a down-regulation of IRX4 expression in the cells undergoing epithelial to mesenchymal transition, suggesting its potential role in PCa progression and aim to delineate the androgenmediated regulation of IRX4 in PCa. |
| Formato |
application/pdf |
| Identificador | |
| Publicador |
Blackwell Publishing |
| Relação |
http://eprints.qut.edu.au/94798/8/94798.pdf http://onlinelibrary.wiley.com/doi/10.1111/bju.2015.116.issue-S1/issuetoc Panchadsaram, Janatththani, Tevz, Gregor, Stylianou, Nataly, Hollier, Brett G., & Nelson, Colleen (2015) A multiple nucleotide length polymorphism (MNLP) mediates androgen regulation of IRX4 in prostate cancer. In 2nd Prostate Cancer World Congress, 17-21 August 2015, Cairns Convention Centre, Cairns, Qld. |
| Direitos |
2015 The Authors |
| Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
| Palavras-Chave | #111201 Cancer Cell Biology #111203 Cancer Genetics #Multiple nucleotide length polymorphism #MNLP #androgen regulation #IRX4 #prostate cancer |
| Tipo |
Conference Item |
