Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system
| Data(s) |
1981
|
|---|---|
| Resumo |
In reporting a total synthesis of erythromycin (la) we described in the preceding paper1 the synthesis of the erythronolide A seco acid derivative 2 in optically active form. In this paper we wish to report a successful transformation of 2 to 12 (synthetically equivalent to erythronolide A) via lactonization and also demonstrate that the proper functionalization of a substrate is critical for the successful lactonization. |
| Formato |
application/pdf |
| Identificador |
http://eprints.iisc.ernet.in/25679/1/61.pdf Woodward, RB and Logusch, E and Nambiar, KP and Sakan, K and Ward, DE and Au-Yeung, BW and Balaram, P (1981) Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system. In: Journal of the American Chemical Society, 103 (11). pp. 3213-3215. |
| Publicador |
American Chemical Society |
| Relação |
http://pubs.acs.org/doi/abs/10.1021/ja00401a050?prevSearch=Asymmetric%2Btotal%2Bsynthesis%2Bof%2Berythromycin.%2B2.%2BSynthesis%2Bof%2Ban%2Berythronolide%2BA%2Blactone%2Bsystem&searchHistoryKey= http://eprints.iisc.ernet.in/25679/ |
| Palavras-Chave | #Molecular Biophysics Unit |
| Tipo |
Editorials/Short Communications PeerReviewed |
