Genome-wide association study of prostate cancer-specific survival

Autoria(s): Szulkin, R.; Karlsson, R.; Whitington, T.; Aly, M.; Gronberg, H.; Eeles, R.A.; Easton, D.F.; Kote-Jarai, Z.; Al Olama, A.A.; Benlloch, S.; Muir, K.; Giles, G.G.; Southey, M.C.; FitzGerald, L.M.; Henderson, B.E.; Schumacher, F.R.; Haiman, C.A.; Sipeky, C.; Tammela, T.L.J.; Nordestgaard, B.G.; Key, T.J.; Travis, R.C.; Neal, D.E.; Donovan, J.L.; Hamdy, F.C.; Pharoah, P.D.P.; Pashayan, N.; Khaw, K.-T.; Stanford, J.L.; Thibodeau, S.N.; McDonnell, S.K.; Schaid, D.J.; Maier, C.; Vogel, W.; Luedeke, M.; Herkommer, K.; Kibel, A.S.; Cybulski, C.; Lubi ski, J.; Klu niak, W.; Cannon-Albright, L.; Brenner, H.; Herrmann, V.; Holleczek, B.; Park, J.Y.; Sellers, T.A.; Lim, H.-Y.; Slavov, C.; Kaneva, R.P.; Mitev, V.I.; Spurdle, A.; Teixeira, M.R.; Paulo, P.; Maia, S.; Pandha, H.; Michael, A.; Kierzek, A.; Batra, J.; Clements, J.A.; Albanes, D.; Andriole, G.L.; Berndt, S.I.; Chanock, S.; Gapstur, S.M.; Giovannucci, E.L.; Hunter, D.J.; Kraft, P.; Le Marchand, L.; Ma, J.; Mondul, A.M.; Penney, K.L.; Stampfer, M.J.; Stevens, V.L.; Weinstein, S.J.; Trichopoulou, A.; Bueno-de-Mesquita, B.H.; Tjonneland, A.; Cox, D.G.; Maehle, L.; Schleutker, J.; Lindstrom, S.; Wiklund, F.
Data(s)

01/11/2015
Resumo

BACKGROUND: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. METHODS: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). RESULTS: We observed no significant association between genetic variants and prostate cancer survival. CONCLUSIONS: Common genetic variants with large impact on prostate cancer survival were not observed in this study. IMPACT: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.
Identificador

http://eprints.qut.edu.au/94530/
Publicador

American Association for Cancer Research
Relação

DOI:10.1158/1055-9965.EPI-15-0543

Szulkin, R., Karlsson, R., Whitington, T., Aly, M., Gronberg, H., Eeles, R.A., Easton, D.F., Kote-Jarai, Z., Al Olama, A.A., Benlloch, S., Muir, K., Giles, G.G., Southey, M.C., FitzGerald, L.M., Henderson, B.E., Schumacher, F.R., Haiman, C.A., Sipeky, C., Tammela, T.L.J., Nordestgaard, B.G., Key, T.J., Travis, R.C., Neal, D.E., Donovan, J.L., Hamdy, F.C., Pharoah, P.D.P., Pashayan, N., Khaw, K.-T., Stanford, J.L., Thibodeau, S.N., McDonnell, S.K., Schaid, D.J., Maier, C., Vogel, W., Luedeke, M., Herkommer, K., Kibel, A.S., Cybulski, C., Lubi ski, J., Klu niak, W., Cannon-Albright, L., Brenner, H., Herrmann, V., Holleczek, B., Park, J.Y., Sellers, T.A., Lim, H.-Y., Slavov, C., Kaneva, R.P., Mitev, V.I., Spurdle, A., Teixeira, M.R., Paulo, P., Maia, S., Pandha, H., Michael, A., Kierzek, A., Batra, J., Clements, J.A., Albanes, D., Andriole, G.L., Berndt, S.I., Chanock, S., Gapstur, S.M., Giovannucci, E.L., Hunter, D.J., Kraft, P., Le Marchand, L., Ma, J., Mondul, A.M., Penney, K.L., Stampfer, M.J., Stevens, V.L., Weinstein, S.J., Trichopoulou, A., Bueno-de-Mesquita, B.H., Tjonneland, A., Cox, D.G., Maehle, L., Schleutker, J., Lindstrom, S., & Wiklund, F. (2015) Genome-wide association study of prostate cancer-specific survival. Cancer Epidemiology, Biomarkers and Prevention, 24(11), pp. 1796-1800.
Fonte

School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation
Palavras-Chave #111200 ONCOLOGY AND CARCINOGENESIS #111201 Cancer Cell Biology
Tipo

Journal Article
Acesso ao item digital