Potential antioxidant response to coffee - A matter of genotype?
| Data(s) |
01/12/2014
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|---|---|
| Resumo |
In a human intervention trial, a coffee, combining nature green coffee bean constituents and dark roast products was studied towards its potential to activate the Nrf2/ARE-pathway in PBLs. The study coffee was identified as a strong inducer of Nrf2 and downstream GST1A1 and UGT1A1 gene transcription. However, the response of the participants was found to depend on the respective genotype. The -651 SNP in the Nrf2 gene as well as the heterozygote 6/7 sequence in the UGT1A1 gene significantly down-regulated the susceptibility to respond to coffee, proposing the existing genotype to be critical for the response to the coffee. |
| Formato |
application/pdf |
| Identificador | |
| Publicador |
Elsevier |
| Relação |
http://eprints.qut.edu.au/94390/1/Boettler%20et%20al%20MetaGene%202014.pdf DOI:10.1016/j.mgene.2014.07.003 Hassmann, Ute, Haupt, Larisa M., Smith, Robert A., Winkler, Swantje, Bytof, Gerhard, Lantz, Ingo, Griffiths, Lyn R., & Marko, Doris (2014) Potential antioxidant response to coffee - A matter of genotype? MetaGene, 2, pp. 525-539. |
| Direitos |
2014 The Author(s) This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). |
| Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
| Palavras-Chave | #Reactive oxygen species #antioxidant #coffee #Nrf genotype #GST1A1 genotype #UGT1A1 genotype #genetic variations #gene expression |
| Tipo |
Journal Article |
