Encapsulation and release of rifampicin using poly(vinyl pyrrolidone)-poly (methacrylic acid) polyelectrolyte capsules
Data(s) |
15/10/2009
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Resumo |
Poly(vinyl pyrrolidone) and poly(methacrylic acid) multilayer capsules based on hydrogen bonding have been prepared by the layer-by-layer approach and used to encapsulate and release rifampicin, an antituberculosis drug. Removal of silica core using a buffer of ammonium fluoride and hydrofluoric acid at about pH 3 was found to produce better capsules than hydrofluoric acid alone. An eight-layered capsule had a wall thickness of 20 rim. Maximum encapsulation was found to be about 86 mu g at 40 degrees C with 1 +/- 0.2 x 10(6) capsules. Release studies showed a burst kind of release and maximum release was obtained above pH 7 where the capsules disintegrate rapidly thereby releasing the drug in a short period. Interactions studies with Mycobacterium smegmatis showed that the capsules were cytocompatible and the released drug functioned with the same efficacy as the free drug. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/24974/1/4.pdf Kumar, Anil KN and Ray, Basu S and Nagaraja, Valakunja and Raichur, Ashok M (2009) Encapsulation and release of rifampicin using poly(vinyl pyrrolidone)-poly (methacrylic acid) polyelectrolyte capsules. In: Materials Science and Engineering: C, 29 (8). pp. 2508-2513. |
Publicador |
Elsevier Science |
Relação |
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TXG-4WYDMY5-2&_user=512776&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000025298&_version=1&_urlVersion=0&_userid=512776&md5=67d7d2512e02fb0582d3d80832aa1a56 http://eprints.iisc.ernet.in/24974/ |
Palavras-Chave | #Materials Engineering (formerly Metallurgy) #Microbiology & Cell Biology |
Tipo |
Journal Article PeerReviewed |