Stereochemistry of peptides and polypeptides containing omega amino acids


Autoria(s): Banerjee, A; Balaram, P
Data(s)

25/12/1997

Resumo

The omega amino acids have a larger degree of conformational variability than the alpha amino acids, leading to a greater diversity of backbone structures in peptides and polypeptides. The synthetic accessibility of chiral beta-amino acids and the recent observation of novel helical folds in oligomers of cyclic beta-amino acids has led to renewed interest in the stereochemistry of omega-amino acid containing peptides. This review focuses on the conformational characteristics of the polymethylene chain in omega-amino acid segments and surveys structural features in peptides established by X-ray diffraction. The literature on polymers of achiral omega-amino acids (nylon derivatives) and chiral, substituted derivatives derived from trifunctional alpha-amino acids, reveals that while sheet-like, intermolecular hydrogen bonded structures are formed by the former, folded helices appear favoured by the latter. omega-Amino acids promise to expand the repertoire of peptide folds.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/24856/1/3.pdf

Banerjee, A and Balaram, P (1997) Stereochemistry of peptides and polypeptides containing omega amino acids. In: Current science, 73 (12). pp. 1067-1077.

Publicador

Indian academy of sciences

Relação

http://www.ias.ac.in/j_archive/currsci/73/vol73contents.html

http://eprints.iisc.ernet.in/24856/

Palavras-Chave #Molecular Biophysics Unit
Tipo

Journal Article

PeerReviewed