Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands

Autoria(s): Raval, Saurin; Raval, Preeti; Bandyopadhyay, Debdutta; Soni, Krunal; Yevale, Digambar; Jogiya, Digvijay; Modi, Honey; Joharapurkar, Amit; Gandhi, Neha; Jain, Mukul R.; Patel, Pankaj R.
Data(s)

2008
Resumo

Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy-cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor β.
Identificador

http://eprints.qut.edu.au/93840/
Publicador

Elsevier
Relação

DOI:10.1016/j.bmcl.2008.06.038

Raval, Saurin, Raval, Preeti, Bandyopadhyay, Debdutta, Soni, Krunal, Yevale, Digambar, Jogiya, Digvijay, Modi, Honey, Joharapurkar, Amit, Gandhi, Neha, Jain, Mukul R., & Patel, Pankaj R. (2008) Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands. Bioorganic & Medicinal Chemistry Letters, 18(14), pp. 3919-3924.
Fonte

Science & Engineering Faculty
Tipo

Journal Article
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