Oxazolidine-2-thiones: A molecular modeling study
| Data(s) |
09/08/2004
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|---|---|
| Resumo |
Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding. |
| Identificador | |
| Publicador |
Elsevier |
| Relação |
DOI:10.1016/j.tetlet.2004.06.090 Gandhi, Neha, Srivastava, Brijesh K., Lohray, Vidya B., & Lohray, Braj B. (2004) Oxazolidine-2-thiones: A molecular modeling study. Tetrahedron Letters, 45(33), pp. 6269-6272. |
| Direitos |
Copyright 2004 Elsevier Ltd. |
| Fonte |
School of Mathematical Sciences; Science & Engineering Faculty |
| Palavras-Chave | #Oxazolidine-2-thiones; Linezolid; Molecular modeling; 23S rRNA; Antibacterial; Piecewise linear potential (PLP); Thioacetamide |
| Tipo |
Journal Article |
