Oxazolidine-2-thiones: A molecular modeling study


Autoria(s): Gandhi, Neha; Srivastava, Brijesh K.; Lohray, Vidya B.; Lohray, Braj B.
Data(s)

09/08/2004

Resumo

Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding.

Identificador

http://eprints.qut.edu.au/93824/

Publicador

Elsevier

Relação

DOI:10.1016/j.tetlet.2004.06.090

Gandhi, Neha, Srivastava, Brijesh K., Lohray, Vidya B., & Lohray, Braj B. (2004) Oxazolidine-2-thiones: A molecular modeling study. Tetrahedron Letters, 45(33), pp. 6269-6272.

Direitos

Copyright 2004 Elsevier Ltd.

Fonte

School of Mathematical Sciences; Science & Engineering Faculty

Palavras-Chave #Oxazolidine-2-thiones; Linezolid; Molecular modeling; 23S rRNA; Antibacterial; Piecewise linear potential (PLP); Thioacetamide
Tipo

Journal Article