Studies on the Mechanism of Action of Miconazole: Effect of Miconazole on Respiration and Cell Permeability of Candida albicans


Autoria(s): Swamy, KH Sreedhara; Sirsi, M; Rao, G Ramananda
Data(s)

01/04/1974

Resumo

The antifungal drug, miconazole nitrate, inhibits the growth of several species of Candida. Candida albicans, one of the pathogenic species, was totally inhibited at a concentration of approximately 10 µg/ml. Endogenous respiration was unaffected by the drug at a concentration as high as 100 µg/ml, whereas exogenous respiration was markedly sensitive and inhibited to an extent of 85%. The permeability of the cell membrane was changed as evidenced by the leakage of 260-nm absorbing materials, amino acids, proteins, and inorganic cations. The results we present clearly show that the drug alters the cellular permeability, and thus the exogenous respiration becomes sensitive to the drug.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/23597/1/fulltext.pdf

Swamy, KH Sreedhara and Sirsi, M and Rao, G Ramananda (1974) Studies on the Mechanism of Action of Miconazole: Effect of Miconazole on Respiration and Cell Permeability of Candida albicans. In: Antimicrobial Agents and Chemotherapy, 5 (4). pp. 420-425.

Publicador

American Society for Microbiology

Relação

http://aac.asm.org/cgi/content/abstract/5/4/420

http://eprints.iisc.ernet.in/23597/

Palavras-Chave #Microbiology & Cell Biology
Tipo

Journal Article

PeerReviewed