Commentary: Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: A potential paradigm shift


Autoria(s): Banas, Sophie M.; Diaz, Silvina L.; Doly, Stephane; Belmer, Arnauld; Maroteaux, Luc
Data(s)

05/08/2015

Resumo

Working on the serotonin (5-hydroxytryptamine, 5-HT) 5-HT2B receptor since several years, we have read with high interest the review by Hertz et al. (2015). Previous studies from our group demonstrated that a direct injection in mouse raphe nucleus of the 5-HT2B agonist BW723C86 has the ability to increase extracellular levels of serotonin, which can be blocked by the selective 5-HT2B receptor antagonist RS127445 (Doly et al., 2008, 2009). We also reported that an acute injection of paroxetine 2 mg/kg in mice knocked out for the 5-HT2B receptor gene or in wild type mice injected with RS127445 (0.5 mg/kg) triggers a strong reduction in extracellular accumulation of 5-HT in hippocampus (Diaz et al., 2012). Following these observations, we showed that acute and chronic BW723C86 injection (3 mg/kg) can mimic the fluoxetine (3 mg/kg) and paroxetine (1 mg/kg) behavioral and biochemical antidepressant effects in mice (Diaz and Maroteaux, 2011; Diaz et al., 2012)...

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/92283/

Publicador

Frontiers Research Foundation

Relação

http://eprints.qut.edu.au/92283/1/fnbeh-09-00207.pdf

http://journal.frontiersin.org/article/10.3389/fnbeh.2015.00207/pdf

DOI:10.3389/fnbeh.2015.00207

Banas, Sophie M., Diaz, Silvina L., Doly, Stephane, Belmer, Arnauld, & Maroteaux, Luc (2015) Commentary: Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: A potential paradigm shift. Frontiers in Behavioral Neuroscience, 9(207).

Direitos

Copyright 2015 Banas, Diaz, Doly, Belmer and Maroteaux.

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Fonte

School of Clinical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation

Palavras-Chave #5-HT2B #receptor #SSRI #serotonin
Tipo

Journal Article