Cross-sectional study of a microsatellite marker in the low density lipoprotein receptor gene in obese normotensives
Data(s) |
1995
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Resumo |
1. The low density lipoprotein receptor is an important regulator of serum cholesterol which may have implications for the development of both hypertension and obesity. In this study, genotypes for a low density lipoprotein receptor gene (LDLR) dinucleotide polymorphism were determined in both lean and obese normotensive populations. 2. In previous cross-sectional association studies an ApaLI and a HincII polymorphism for LDLR were shown to be associated with obesity in essential hypertensives. However, these polymorphisms did not show an association with obesity in normotensives. 3. In contrast, this study reports that preliminary results for an LDLR microsatellite marker, located more towards the 3' end of the gene, show a significant association with obesity in the normotensive population studied. These results indicate that LDLR could play an important role in the development of obesity, which might be independent of hypertension. |
Identificador | |
Publicador |
Wiley-Blackwell Publishing Asia |
Relação |
DOI:10.1111/j.1440-1681.1995.tb02056.x Griffiths, L. R., Nyholt, D. R., Curtain, R. P., Gaffney, P. T., & Morris, B. J. (1995) Cross-sectional study of a microsatellite marker in the low density lipoprotein receptor gene in obese normotensives. Clinical and Experimental Pharmacology & Physiology, 22(6-7), pp. 496-498. |
Direitos |
Copyright 1995 Wiley-Blackwell Publishing Asia |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #Chi-Square Distribution #Cholesterol/*blood #Cross-Sectional Studies #DNA #Satellite/genetics #Electrophoresis #Polyacrylamide Gel #Genetic Markers #Genotype #Humans #Hypertension/etiology/physiopathology #Obesity/*etiology/physiopathology #Polymerase Chain Reaction #Polymorphism #Genetic #Receptors #LDL/*genetics #Repetitive Sequences #Nucleic Acid |
Tipo |
Journal Article |