Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
| Data(s) |
2009
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| Resumo |
We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 x 10(-20)), transferrin saturation (combined P = 2.2 x 10(-23)) and erythrocyte mean cell volume (MCV, combined P = 1.1 x 10(-10)). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 x 10(-7)). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis. |
| Identificador | |
| Publicador |
Nature Publishing Group |
| Relação |
DOI:10.1038/ng.456 Benyamin, B., Ferreira, M. A., Willemsen, G., Gordon, S., Middelberg, R. P., McEvoy, B. P., Hottenga, J. J., Henders, A. K., Campbell, M. J., Wallace, L., Frazer, I. H., Heath, A. C., de Geus, E. J., Nyholt, D.R., Visscher, P. M., Penninx, B. W., Boomsma, D. I., Martin, N. G., Montgomery, G. W., & Whitfield, J. B. (2009) Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nature Genetics, 41(11), pp. 1173-5. |
| Direitos |
Copyright 2009 Nature America Inc. |
| Fonte |
Faculty of Health; Institute of Health and Biomedical Innovation |
| Palavras-Chave | #Chromosomes #Human #Pair 22 #*Erythrocyte Volume #Erythrocytes/*cytology/*metabolism #Genome-Wide Association Study #*Homeostasis #Humans #Iron/*blood #Membrane Proteins/*genetics #*Polymorphism #Single Nucleotide #Serine Endopeptidases/*genetics #Transferrin/metabolism |
| Tipo |
Journal Article |
