Host-specificity of Salmonella enterica serovar Gallinarum: Insights from comparative genomics


Autoria(s): Eswarappa, Sandeepa M; Janice, Jessin; Balasundaram, Sudhagar V; Dixit, Narendra M; Chakravortty, Dipshikha
Data(s)

01/07/2009

Resumo

In this study, we have identified the possible genetic factors responsible for fowl-adaptation of Salmonella enterica serovar Gallinarum (S. Gallinarum). By comparing the genes related to Salmonella pathogenicity islands (SPI) of S. Gallinarum with those of Salmonella enterica serovar Enteritidis (S. Enteritidis) we have identified twenty-four positively selected genes. Our results suggest that the genes encoding the structural components of SPI-2 encoded type three secretion apparatus (TTSS) and the effector proteins that are secreted via SPI-1 encoded TTSS have evolved under positive selection pressure in these serovars. We propose that these positively selected genes play important roles in conferring different host-specificities to S. Gallinarum and S. Enteritidis.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/21340/1/mk.pdf

Eswarappa, Sandeepa M and Janice, Jessin and Balasundaram, Sudhagar V and Dixit, Narendra M and Chakravortty, Dipshikha (2009) Host-specificity of Salmonella enterica serovar Gallinarum: Insights from comparative genomics. In: Infection Genetics and Evolution, 9 (4). pp. 468-473.

Publicador

Elsevier Science

Relação

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W8B-4VDH8Y5-3&_user=512776&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000025298&_version=1&_urlVersion=0&_userid=512776&md5=424e2633ba1d675843920150b7cd2d7b

http://eprints.iisc.ernet.in/21340/

Palavras-Chave #Microbiology & Cell Biology
Tipo

Journal Article

PeerReviewed