The biochemistry of blister fluid from pediatric burn injuries: proteomics and metabolomics aspects
Data(s) |
18/11/2015
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Resumo |
Burn injury is a prevalent and traumatic event for pediatric patients. At present, the diagnosis of burn injury severity is subjective and lacks a clinically relevant quantitative measure. This is due in part to a lack of knowledge surrounding the biochemistry of burn injuries and that of blister fluid. A more complete understanding of the blister fluid biochemistry may open new avenues for diagnostic and prognostic development. Burn insult induces a highly complex network of signaling processes and numerous changes within various biochemical systems, which can ultimately be examined using proteome and metabolome measurements. This review reports on the current understanding of burn wound biochemistry and outlines a technical approach for ‘omics’ profiling of blister fluid from burn wounds of differing severity. |
Identificador | |
Publicador |
Taylor & Frances |
Relação |
DOI:10.1586/14789450.2016.1122528 Tuo, Zang, Broszczak, Daniel, Broadbent, James A., Cuttle, Leila, Lu, Haitao, & Parker, Tony J. (2015) The biochemistry of blister fluid from pediatric burn injuries: proteomics and metabolomics aspects. Expert review of proteomics. (In Press) http://purl.org/au-research/grants/NHMRC/409902 |
Direitos |
Taylor & Frances |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #110100 MEDICAL BIOCHEMISTRY AND METABOLOMICS #pediatric burns #mass spectrometry #proteomics #metabolomics #nuclear magnetic resonance #blister fluid |
Tipo |
Journal Article |