Short-term nutritional supplementation during management of pulmonary exacerbations in cystic fibosis: A controlled study, including effects of protein turnover


Autoria(s): Shepherd, R. W.; Holt, T. L.; Cleghorn, Geoffrey J.; Ward, L. C.; Isles, A.; Francis, P.
Data(s)

1988

Resumo

Effects of nutritional supplements on minimizing weight loss and abnormalities of protein turnover during pulmonary exacerbations in cystic fibrosis (CF) were studied by controlled trial. Patients received pulmonary therapy and either standard diet (n = 10) or adjunctive enteral supplements (n = 12). Initial protein turnover, measured by [15N]glycine kinetics, showed alterations of protein synthesis (P Syn) and catabolism (P Cat), which correlated with the degree of underweight, and negligible net protein deposition (P Dep). With treatment both groups had significant increases in mean body weight and forced expiratory volume in 1 s, expressed as percent predicted value for height (FEV1) by 3 wk, but a significant correlation between initial underweight and subsequent weight gain was observed only in supplemented patients. Mean P Syn and P Dep increased significantly (p < 0.001) only in the supplemented group. Pulmonary exacerbations in CF have important adverse effects on body-protein metabolism, similar to changes in protein-energy malnutrition and infection. These effects are reversed by short-term nutritional support. Strategic nutritional intervention should thus be considered in management, especially in malnourished patients.

Identificador

http://eprints.qut.edu.au/90749/

Publicador

The American Society for Nutrition

Relação

http://www.scopus.com/inward/record.url?eid=2-s2.0-0023754203&partnerID=40&md5=da017362c77bd906f67d0a7ae733ded4

Shepherd, R. W., Holt, T. L., Cleghorn, Geoffrey J., Ward, L. C., Isles, A., & Francis, P. (1988) Short-term nutritional supplementation during management of pulmonary exacerbations in cystic fibosis: A controlled study, including effects of protein turnover. American Journal of Clinical Nutrition, 48(2), pp. 235-239.

Fonte

Faculty of Health; Institute of Health and Biomedical Innovation; School of Exercise & Nutrition Sciences

Palavras-Chave #adolescent #clinical article #cystic fibrosis #female #human #lung infection #male #nutrition #priority journal #protein metabolism #school child #Body Weight #Child #Clinical Trials #Enteral Nutrition #Forced Expiratory Volume #Lung #Mathematics #Pneumonia #Proteins #Respiration #Support #Non-U.S. Gov't
Tipo

Journal Article