Conformational flexibility in androgenic steroids - the structure of a new form of (+)-17-beta-hydroxy-19-nor-4-androsten-3-one (19-nortestosterone), c18h26o2
Data(s) |
01/11/1984
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Resumo |
The structure and conformation of a second crystalline modification of 19-nortestosterone has been determined by X-ray methods. M r = 274, monoclinic P2 l, a=9.755(2), b= 11.467(3), c= 14.196(3)/L fl=101.07(2) ° , V=1558.4 (8) A 3, Z=4, Ox= I. 168 g cm -3, Mo Ka, 2 = 0.7107 ,/k, ~ = 0.80 cm -l, F(000) = 600, T= 300 K. R = 0.060 for 2158 observed reflections. The two molecules in the asymmetric unit show significant differences in the A-ring conformation from that of the previously reported form of the title compound [Precigoux, Busetta, Courseille & Hospital (1975). Acta Cryst. B31, 1527-1532]. The l a,2fl-half-chair conformation of the A ring increases its conformational freedom compared with testosterone. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/20072/1/3fulltext.pdf Bhadbhade, Mohan M and Vennkatesan, K (1984) Conformational flexibility in androgenic steroids - the structure of a new form of (+)-17-beta-hydroxy-19-nor-4-androsten-3-one (19-nortestosterone), c18h26o2. In: Acta crystallographica section c-crystal structure communications, 40 . pp. 1905-1908. |
Publicador |
International Union of Crystallography |
Relação |
http://journals.iucr.org/c/issues/1984/11/00/a24006/a24006.pdf http://eprints.iisc.ernet.in/20072/ |
Palavras-Chave | #Organic Chemistry |
Tipo |
Journal Article PeerReviewed |