Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal Stenosis
| Data(s) |
2008
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| Resumo |
BACKGROUND AND PURPOSE Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The study explores the relationship between the degree of Magnetic Resonance (MR)"defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide (USPIO) particles and the severity of luminal stenosis in asymptomatic carotid plaques. METHODS Seventy-one patients with an asymptomatic carotid stenosis of ĝ‰¥40% underwent multi-sequence USPIO-enhanced MR imaging. Stenosis severity was measured according to the NASCET and ECST methods. RESULTS No demonstrable relationship between inflammation as measured by USPIO-enhanced signal change and the degree of luminal stenosis was found. CONCLUSIONS Inflammation and stenosis are likely to be independent risk factors, although this needs to be further validated. |
| Identificador | |
| Publicador |
Lippincott Williams & Wilkins |
| Relação |
DOI:10.1161/STROKEAHA.107.504753 Tang, T. Y., Howarth, S. P. S., Miller, S. R., Graves, M. J., U-King-Im, J. M., Li, Z. Y., Walsh, S. R., Patterson, A. J., Kirkpatrick, P. J., Warburton, E. A., Varty, K., Gaunt, M. E., & Gillard, J. H. (2008) Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal Stenosis. Stroke, 39(7), pp. 2144-2147. |
| Direitos |
Copyright 2008 American Heart Association, Inc. |
| Fonte |
School of Chemistry, Physics & Mechanical Engineering; Institute of Health and Biomedical Innovation; Science & Engineering Faculty |
| Palavras-Chave | #Asymptomatic carotid stenosis #Atherosclerosis #Inflammation #MRI #Plaque vulnerability #USPIO |
| Tipo |
Journal Article |
