Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles
| Data(s) |
01/05/2009
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| Resumo |
A new class of 1,3,4-oxadiazoles were prepared from acid hydrazides on treatment with different carboxylic acids in the presence of phosphorus oxychloride. Interconversion of oxadiazoles to thiadiazoles and triazoles was carried out with appropriate reagents. The antimicrobial and cytotoxic activities of compounds 7a-d to 12a-d were tested. Compounds 10d and 12d showed pronounced antimicrobial activity. Further, compound 10d exhibited maximum cytotoxicity. (C) 2008 Elsevier Masson SAS. All rights reserved. |
| Formato |
application/pdf |
| Identificador |
http://eprints.iisc.ernet.in/20033/1/fulltext.pdf V, Padmavathi and Reddy, G Sudhakar and Padmaja, A and Kondaiah, P and Ali, Shazia (2009) Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles. In: European Journal of Medicinal Chemistry, 44 (5). pp. 2106-2112. |
| Publicador |
Elsevier Science |
| Relação |
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VKY-4TTMJHX-5&_user=512776&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000025298&_version=1&_urlVersion=0&_userid=512776&md5=fe3372899834a0fa0db4a9013d863a27 http://eprints.iisc.ernet.in/20033/ |
| Palavras-Chave | #Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME) |
| Tipo |
Journal Article PeerReviewed |
