Nutritional rehabilitation in cystic fibrosis: A 5 year follow-up study


Autoria(s): Dalzell, A. M.; Shepherd, R. W.; Dean, B.; Cleghorn, Geoffrey J.; Holt, T. L.; Francis, P. J.
Data(s)

1992

Resumo

Previously, we reported catch-up weight gain, growth, and improved lung function in a group of malnourished cystic fibrosis (CF) children receiving aggressive nutritional supplementation for 1 year compared with a forced expiratory volume in 1 s (FEV<inf>1</inf>)-, height-, and sex-matched comparison group receiving standard therapy. To evaluate long-term effects, the clinical progress of both groups has been studied over a 5 year period. The supplemented group (n = 10) received supplements for a median of 1.35 years to achieve nutritional rehabilitation. Compared with the nonsupplemented group (n = 14), the previously supplemented group had lower mortality (2 vs. 4, N.S.) and significantly greater weight and height z scores at 4 and 5 years. The progression of pulmonary function abnormalities as measured by FEV, and forced vital capacity (FVC) slopes was greater at 3 years in the nonsupplemented group (FEV<inf>1</inf>, p < 0.05) but no significant differences in rates of deterioration of pulmonary function were seen after 5 years in the two groups of survivors. We conclude that intensive nutritional support for 1 year has both short-and long-term effects on nutrition and growth, still evident some years after the cessation of this therapeutic modality. Supplementation for periods of longer than 1 year may produce greater gains and possibly prolong the improvement in pulmonary function observed in the earlier study. © 1992 Raven Press, Ltd., New York.

Identificador

http://eprints.qut.edu.au/90258/

Publicador

Lippincott Williams & Wilkins

Relação

http://www.scopus.com/inward/record.url?eid=2-s2.0-0026659185&partnerID=40&md5=303233a261482a3f3367c5669c681a8a

Dalzell, A. M., Shepherd, R. W., Dean, B., Cleghorn, Geoffrey J., Holt, T. L., & Francis, P. J. (1992) Nutritional rehabilitation in cystic fibrosis: A 5 year follow-up study. Journal of Pediatric Gastroenterology and Nutrition, 15(2), pp. 141-145.

Fonte

Faculty of Health; Institute of Health and Biomedical Innovation; School of Exercise & Nutrition Sciences

Palavras-Chave #Cystic fibrosis #Lung function #Nutrition rehabilitation #article #catch up growth #child #clinical article #clinical feature #controlled study #follow up #forced expiratory volume #height #human #malnutrition #mortality #nutritional support #priority journal #weight gain #Adolescent #Adult #Body Height #Enteral Nutrition #Female #Follow-Up Studies #Male #Nutrition Disorders #Nutritional Status
Tipo

Journal Article