Determination of the effect of JO146, a CtHtrA inhibitor, on the chlamydial developmental cycle and persistence
Data(s) |
2015
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Resumo |
The role of Chlamydia trachomatis HtrA (CtHtrA) for the growth and pathogenesis of this organism is presented. Inhibition of CtHtrA led to loss of infectious progeny in Chlamydia, particularly during heat stress or recovery from penicillin persistence. Isolation of CtHtrA inhibitor resistant mutants identified positive selection for mutants in fatty acid related pathways. Importantly, HtrA inhibition was effective against clinical isolates of C. trachomatis. Thus the findings combined indicate that CtHtrA is an important chlamydial growth factor that has the potential to be targeted for the development of anti-chlamydial drugs in the future. |
Formato |
application/pdf |
Identificador | |
Publicador |
Queensland University of Technology |
Relação |
http://eprints.qut.edu.au/89931/1/Vanissa_Ong_Thesis.pdf Ong, Vanissa A. (2015) Determination of the effect of JO146, a CtHtrA inhibitor, on the chlamydial developmental cycle and persistence. PhD thesis, Queensland University of Technology. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #Chlamydia trachomatis #intracellular pathogen #clinical isolate #HtrA #protease #inhibitor #mutants #developmental cycle |
Tipo |
Thesis |