Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo
| Data(s) |
2013
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|---|---|
| Resumo |
Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer)while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma. |
| Identificador | |
| Publicador |
Royal Society of Chemistry |
| Relação |
DOI:10.1039/c3cc00127j Coles, Daniel J., Rolfe, Barbara E., Boase, Nathan R.B., Veedu, Rakesh N., & Thurecht, Kristofer J. (2013) Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo. Chemical Communications, 49(37), pp. 3836-3838. |
| Direitos |
Copyright 2013 Royal Society of Chemistry |
| Fonte |
School of Chemistry, Physics & Mechanical Engineering; Science & Engineering Faculty |
| Tipo |
Journal Article |
