Development and characterisation of a new bioink for additive tissue manufacturing
Data(s) |
2014
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Resumo |
Additive manufacturing forms a potential route towards economically viable production of cellular constructs for tissue engineering. Hydrogels are a suitable class of materials for cell delivery and 3D culture, but are generally unsuitable as construction materials. Gelatine-methacrylamide is an example of such a hydrogel system widely used in the field of tissue engineering, e.g. for cartilage and cardiovascular applications. Here we show that by the addition of gellan gum to gelatine-methacrylamide and tailoring salt concentrations, rheological properties such as pseudo-plasticity and yield stress can be optimised towards gel dispensing for additive manufacturing processes. In the hydrogel formulation, salt is partly substituted by mannose to obtain isotonicity and prevent a reduction in cell viability. With this, the potential of this new bioink for additive tissue manufacturing purposes is demonstrated. |
Identificador | |
Publicador |
RSC Publications |
Relação |
DOI:10.1039/C3TB21280G Melchels, Ferry P.W., Dhert, Wouter J.A., Hutmacher, Dietmar W., & Malda, Jos (2014) Development and characterisation of a new bioink for additive tissue manufacturing. Journal of Materials Chemistry B, 2(16), pp. 2282-2289. http://purl.org/au-research/grants/ARC/FT110101117 |
Fonte |
School of Chemistry, Physics & Mechanical Engineering; Institute of Health and Biomedical Innovation; Science & Engineering Faculty |
Tipo |
Journal Article |