Prognostic value of BRAF mutations in localized cutaneous melanoma
Data(s) |
01/05/2014
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Resumo |
BACKGROUND: BRAF mutations are frequent in melanoma but their prognostic significance remains unclear. OBJECTIVE: We sought to further evaluate the prognostic value of BRAF mutations in localized cutaneous melanoma. METHODS: We undertook an observational retrospective study of 147 patients with localized invasive (stages I and II) cutaneous melanomas to determine the prognostic value of BRAF mutation status. RESULTS: After a median follow-up of 48 months, patients with localized melanomas with BRAF-mutant melanomas exhibited poorer disease-free survival than those with BRAF-wt genotype (hazard ratio 2.2, 95% confidence interval 1.1-4.3) even after adjustment for Breslow thickness, tumor ulceration, location, age, sex, and tumor mitotic rate. LIMITATIONS: The retrospective design and the small number of events are limitations. CONCLUSIONS: Our findings suggest that reappraisal of clinical treatment approaches for patients with localized melanoma harboring tumors with BRAF mutation might be warranted |
Identificador | |
Publicador |
Mosby, Inc. |
Relação |
DOI:10.1016/j.jaad.2013.10.064 Nagore, Eduardo, Requena, Celia, Traves, Victor, Guillen, Carlos, Hayward, Nicholas K, Whiteman, David C, & Hacker, Elke (2014) Prognostic value of BRAF mutations in localized cutaneous melanoma. Journal of the American Academy of Dermatology, 70(5), pp. 858-862. |
Fonte |
Faculty of Health; Institute of Health and Biomedical Innovation; School of Public Health & Social Work |
Palavras-Chave | #BRAF #localized #melanoma #NRAS #prognosis #survival |
Tipo |
Journal Article |