The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis
Data(s) |
1998
|
---|---|
Resumo |
Objective. To analyze the effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis (AS). Methods. Three hundred sixty- three white British AS patients were studied; 149 were carefully assessed for a range of clinical manifestations, and disease severity was assessed using a structured questionnaire. Limited HLA class I typing and complete HLA-DR typing were performed using DNA-based methods. HLA data from 13,634 healthy white British bone marrow donors were used for comparison. Results. A significant association between DR1 and AS was found, independent of HLA-B27 (overall odds ratio [OR] 1.4, 95% confidence interval [95% CI] 1.1-1.8, P = 0.02; relative risk [RR] 2.7, 95% CI 1.5-4.8, P = 6 x 10-4 among homozygotes; RR 2.1, 95% CI 1.5-2.8, P = 5 x 10-6 among heterozygotes). A large but weakly significant association between DR8 and AS was noted, particularly among DR8 homozygotes (RR 6.8, 95% CI 1.6-29.2, P = 0.01 among homozygotes; RR 1.6, 95% CI 1.0-2.7, P = 0.07 among heterozygotes). A negative association with DR12 (OR 0.22, 95% CI 0.09-0.5, P = 0.001) was noted. HLA-DR7 was associated with younger age at onset of disease (mean age at onset 18 years for DR7-positive patients and 23 years for DR7-negative patients; Z score 3.21, P = 0.001). No other HLA class I or class H associations with disease severity or with different clinical manifestations of AS were found. Conclusion. The results of this study suggest that HLA-DR genes may have a weak effect on susceptibility to AS independent of HLA-B27, but do not support suggestions that they affect disease severity or different clinical manifestations. |
Identificador | |
Publicador |
John Wiley & Sons, Inc. |
Relação |
DOI:10.1002/1529-0131(199803)41:3<460::AID-ART12>3.0.CO;2-X Brown, Matthew A., Kennedy, L. G., Darke, C., Gibson, K., Pile, K. D., Shatford, J. L., Taylor, A., Calin, A., & Wordsworth, B. P. (1998) The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis. Arthritis and Rheumatism, 41(3), pp. 460-465. |
Fonte |
School of Biomedical Sciences; Institute of Health and Biomedical Innovation |
Palavras-Chave | #HLA antigen class 1 #HLA DR antigen #adult #aged #ankylosing spondylitis #article #bone marrow cell #disease severity #drug effect #female #gene linkage disequilibrium #genetic susceptibility #HLA typing #human #major clinical study #male #priority journal #restriction fragment length polymorphism #Age of Onset #Arthritis #Genetic Predisposition to Disease #Heterozygote #HLA-DR Antigens #Homozygote #Humans #Risk Factors #Spondylitis #Ankylosing |
Tipo |
Journal Article |