Molecular genetic investigation of mitochondrial dysfunction in relation to migraine susceptibility
Data(s) |
2015
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Resumo |
The aim of this research was to assess the role of genetic variation in mitochondrial function and how this relates to migraine pathophysiology. Using our unique Norfolk Island population, a custom in-house next generation sequencing methodology was developed. This data for the first time showed that there is a molecular genetic link between mitochondrial dysfunction and migraine susceptibility. This work has provided the foundation for further studies aimed at utilising the identified markers in improved migraine diagnostic and therapeutic strategies. |
Formato |
application/pdf |
Identificador | |
Publicador |
Queensland University of Technology |
Relação |
http://eprints.qut.edu.au/84899/1/Shani_Stuart_Thesis.pdf Stuart, Shani (2015) Molecular genetic investigation of mitochondrial dysfunction in relation to migraine susceptibility. PhD thesis, Queensland University of Technology. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #Migraine Susceptibility #Mitochondrial Dysfunction #Molecular Genetics #Next Generation Sequencing #Norfolk Island #Ion Torrent #Oxidative Phosphorylation #Haplogroups #Ancestry #Nuclear Encoded Mitochondrial Proteins |
Tipo |
Thesis |