Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules
Data(s) |
01/12/2010
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Resumo |
Scope: Coffee is among the most frequently consumed beverages. Its consumption is inversely associated to the incidence of diseases related to reactive oxygen species; the phenomenon may be due to its antioxidant properties. Our primary objective was to investigate the impact of consumption of a coffee containing high levels of chlorogenic acids on the oxidation of proteins, DNA and membrane lipids; additionally, other redox biomarkers were monitored in an intervention trial. Methods and results: The treatment group (n=36) consumed instant coffee co-extracted from green and roasted beans, whereas the control consumed water (800 mL/P/day, 5 days). A global statistical analysis of four main biomarkers selected as primary outcomes showed that the overall changes are significant. 8-Isoprostaglandin F2α in urine declined by 15.3%, 3-nitrotyrosine was decreased by 16.1%, DNA migration due to oxidized purines and pyrimidines was (not significantly) reduced in lymphocytes by 12.5 and 14.1%. Other markers such as the total antioxidant capacity were moderately increased; e.g. LDL and malondialdehyde were shifted towards a non-significant reduction. Conclusion: The oxidation of DNA, lipids and proteins associated with the incidence of various diseases and the protection against their oxidative damage may be indicative for beneficial health effects of coffee. |
Identificador | |
Publicador |
Wiley - V C H Verlag GmbH & Co. KGaA |
Relação |
DOI:10.1002/mnfr.201000048 Hoelzl, Christine, Knasmuller, Siegfried, Wagner, Karl-Heinz, Elbling, Leonilla, Huber, Wolfgang, Kager, Nina, Ferk, Franziska, Ehrlich, Veronika, Nersesyan, Armen, Neubauer, Oliver, Desmarchelier, Aurélien, Marin-Kuan, Maricel, Delatour, Thierry, Verguet, Clotilde, Bezencon, Claudine, Besson, Amélie, Grathwohl, Dominik, Simic, Tatjana, Kundi, Michael, Schilter, Benoît, & Cavin, Christophe (2010) Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules. Molecular Nutrition & Food Research, 54(12), pp. 1722-1733. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #110105 Medical Biochemistry - Nucleic Acids #111103 Nutritional Physiology #Antioxidants #Chlorogenic acids #Instant coffee #Interventional trial |
Tipo |
Journal Article |