Determining the kallikrein-related peptidase 4-regulated transcriptome and degradome in the prostate tumour microenvironment
Data(s) |
2015
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Resumo |
Prostate cancer is a leading cause of male cancer-related death and novel therapies are required that prevent progression to terminal disease. This study identified novel protein targets and cell signalling pathways regulated by the prostate cancer-associated protease, kallikrein-related peptidase 4, highlighting it as a promising target for anti-cancer therapy. Seventy-five novel targets and key signalling pathways were identified to be regulated by the protease, suggesting novel functions in remodelling tumour tissue to enable prostate cancer progression. |
Formato |
application/pdf application/zip |
Identificador | |
Publicador |
Queensland University of Technology |
Relação |
http://eprints.qut.edu.au/84094/1/Ruth_Fuhrman-Luck_Thesis.pdf http://eprints.qut.edu.au/84094/9/Ruth%20Fuhrman-Luck%20Supplementary%20Tables%20and%20Figures.zip Fuhrman-Luck, Ruth Anna (2015) Determining the kallikrein-related peptidase 4-regulated transcriptome and degradome in the prostate tumour microenvironment. PhD thesis, Queensland University of Technology. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #Cancer #Degradomics #Transcriptomics #Prostate #Kallikrein-related peptidase #Proteolysis #Tumour microenvironment #Omics #Reactive stroma #Substrate |
Tipo |
Thesis |