The Lymphedema Evaluation in Gynecological cancer Study (LEGS): Design of a prospective, longitudinal, cohort study


Autoria(s): DiSipio, Tracey; Janda, Monika; Hayes, Sandra C.; Reul-Hirche, Hildegard; Ward, Leigh; Obermair, Andreas
Data(s)

2015

Resumo

Background The Lymphoedema Evaluation in Gynecological cancer Study (LEGS) was a longitudinal, observational, cohort study prospectively evaluating the incidence and risk factors of lower-limb lymphedema after treatment for gynecological cancer. Here we describe the study protocol and characteristics of the sample. Methods Women with a newly diagnosed gynecological cancer between June 1, 2008 and February 28, 2011, aged 18 years or older, and treated at one of six hospitals in Queensland, Australia, were eligible. Lymphedema was assessed by circumference measurements, bioimpedance spectroscopy, and self-reported swelling. LEGS incorporated a cohort of patients requiring surgery for benign gynecological conditions for comparison purposes. Data were collected prior to surgery and at regular intervals thereafter up to 2-years post-diagnosis. Results 546 women participated (408 cancer, 138 benign), with a 24-month retention rate of 78%. Clinical and treatment characteristics of participants were similar to the Queensland gynecological cancer population, except for a higher proportion of early-stage cervical cancers recruited to LEGS compared with Queensland proportions (89% versus 55%, respectively). Discussion Few imbalances were observed between participants with complete and incomplete follow-up data. The prospective design and collection of objective and patient-reported outcome data will allow comprehensive assessment of incidence and risk factors of lower-limb lymphedema.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/83514/

Publicador

cancer-research-frontier.org

Relação

http://eprints.qut.edu.au/83514/3/83514.pdf

http://cancer-research-frontiers.org/wp-content/uploads/2015/03/CRF-2015-1-104-1.pdf

DiSipio, Tracey, Janda, Monika, Hayes, Sandra C., Reul-Hirche, Hildegard, Ward, Leigh, & Obermair, Andreas (2015) The Lymphedema Evaluation in Gynecological cancer Study (LEGS): Design of a prospective, longitudinal, cohort study. Cancer Research Frontiers, 1(1), pp. 104-118.

Direitos

Copyright 2015 The Author(s)

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Fonte

Faculty of Health; Institute of Health and Biomedical Innovation; School of Public Health & Social Work

Palavras-Chave #111700 PUBLIC HEALTH AND HEALTH SERVICES #cohort #gynecological cancer #longitudinal #lymphedema #observational #prospective
Tipo

Journal Article