An investigation of the effect of some stable nitroxide antioxidants in prostate cancer cells


Autoria(s): Eng, Grace Tzi Ai
Data(s)

2015

Resumo

The risk of prostate cancer and disease progression may potentially be increased by oxidative stress. This project examined the stability of nitroxide antioxidants and their effects on cell growth, survival and gene regulation in prostate cancer cells. The novel nitroxide, CTMIO, synthesised here at QUT, was found to have minimal toxicity and modulated the expression of a subset of oxidative stress and antioxidant-related genes distinct from those regulated by a related derivative. This study has provided a step forward in our understanding of the mechanism of action of nitroxides within cells.

Formato

application/pdf

Identificador

http://eprints.qut.edu.au/82982/

Publicador

Queensland University of Technology

Relação

http://eprints.qut.edu.au/82982/4/Grace_Eng_Thesis.pdf

Eng, Grace Tzi Ai (2015) An investigation of the effect of some stable nitroxide antioxidants in prostate cancer cells. Masters by Research thesis, Queensland University of Technology.

Fonte

School of Chemistry, Physics & Mechanical Engineering; Institute of Health and Biomedical Innovation; Science & Engineering Faculty

Palavras-Chave #Prostate Cancer #Nitroxides #Oxidative Stress #Antioxidants #Cell Survival #CTMIO #PCR Arrays #Oxidative Stress and Antioxidant-Related Genes #Electron Paramagnetic Resonance
Tipo

Thesis