The role of δ-opioid receptors in learning and memory underlying the development of addiction
Data(s) |
01/01/2015
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Resumo |
Opioids are important endogenous ligands that exist in both invertebrates and vertebrates and signal by activation of opioid receptors to produce analgesia and reward or pleasure. The μ-opioid receptor is the best known of the opioid receptors and mediates the acute analgesic effects of opiates, while the δ-opioid receptor (DOR) has been less well studied and has been linked to effects that follow from chronic use of opiates such as stress, inflammation and anxiety. Recently, DORs have been shown to play an essential role in emotions and increasing evidence points to a role in learning actions and outcomes. The process of learning and memory in addiction has been proposed to involve strengthening of specific brain circuits when a drug is paired with a context or environment. The DOR is highly expressed in the hippocampus, amygdala, striatum and other basal ganglia structures known to participate in learning and memory. In this review, we will focus on the role of the DOR and its potential role in learning and memory underlying the development of addiction. |
Identificador | |
Publicador |
Wiley-Blackwell |
Relação |
DOI:10.1111/bph.2015.172.issue-2 Klenowski, Paul, Morgan, Michael, & Bartlett, Selena E. (2015) The role of δ-opioid receptors in learning and memory underlying the development of addiction. British Journal of Pharmacology, 172(2), pp. 297-310. |
Direitos |
Copyright 1999-2014 John Wiley & Sons, Inc. |
Fonte |
School of Clinical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation |
Palavras-Chave | #110000 MEDICAL AND HEALTH SCIENCES #110300 CLINICAL SCIENCES #110900 NEUROSCIENCES #δ-opioid receptor #enkephalin #ethanol #learning #memory #reward |
Tipo |
Journal Article |